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NMN逆轉動物血管老化

Nicotinamide mononucleotide supplementation reversesvascular dysfunction and oxidative stress with aging in mice

NMN逆轉動物血管老化: 在動物研究中逆轉血管老化，包括恢復舒張心室內徑，降低動脈傳導速度和張力，提高血管彈性，並恢復血管SIRT1活性。 NMN可能是一種通過激活 SIRT1和逆轉血管老化的新療法。

Supplementation with NMN inold mice restored end-diastolic diameter (EDD) and NO‐mediated EDD, reduced aorticpulse wave velocity and elastic modulus, reversed collagen‐I, increasedelastin, and restored vascular SIRT1 activity. NMN may represent a noveltherapy to restore SIRT1 activity and reverse age‐related arterial dysfunctionby decreasing oxidative stress.



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